Activation of PI3-Kinase Is Required for AMPA Receptor Insertion during LTP of mEPSCs in Cultured Hippocampal Neurons
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Activation of PI3-Kinase Is Required for AMPA Receptor Insertion during LTP of mEPSCs in Cultured Hippocampal Neurons
Hippocampal CA1 homosynaptic long-term potentiation (LTP) is expressed specifically at activated synapses. Increased insertion of postsynaptic alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid receptors (AMPARs) appears to be crucial for CA1 LTP. However, the mechanism underlying AMPAR insertion during LTP remains largely unknown. We now report that phosphatidylinositol 3-kinase (PI3K) ...
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Figure 6. Glycine Treatment Enhances NMDA Receptor–Dependent Cell Surface Expression of AMPA Receptors in Cultured Hippocampal Neurons Examples of fluorescent images obtained with a CCD camera (A) illustrate the specific labeling of AMPA receptors expressed on the plasma membrane surface or in the entire cell. Receptors expressed on the cell surface (red) or in the entire cell (green) were sequ...
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AMPAR (α-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid receptor) is an ion channel involved in the formation of synaptic plasticity. However, the molecular mechanism that couples plasticity stimuli to the trafficking of postsynaptic AMPAR remains poorly understood. Here, we show that PIKE (phosphoinositide 3-kinase enhancer) GTPases regulate neuronal AMPAR activity by promoting GluA2/GRIP...
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ژورنال
عنوان ژورنال: Neuron
سال: 2003
ISSN: 0896-6273
DOI: 10.1016/s0896-6273(03)00228-9